ABSTRACT

Thrombophilia is an inborn or accepted disorder of haemostatic mechanism, characterized as an increased tendency for blood coagulation and thrombotization. In gynaecology and especially in obstetrics they play an important role in ethiopathogenesis of many serious conditions and they are connected with higher risk of maternal and perinatal morbidity and mortality. At inborn forms it is especially the mutation of genes coding factor V-Leiden (Leiden mutation), prothrombin G20210A, further hyperhomocysteinaemia, autosomally inherited antithrombine deficit (AT) and C and S proteins. Among accepted forms there are malignity, nephrotic syndrome, protracted immobilisation, myeloprolipherative disease, postoperational conditions etc. Antiphospholipidic sydrome has a specific status.

Key words: thrombophilia – gravidity – coagulation