ABSTRACT

Objective: The aim of this review is to give comprehensive summary of erythrocyte alloimunization of pregnant women, laboratory dignostics and clinical importance.

Design: Review.

Setting: University Hospital Olomouc, Transfusion Department, Department of Obstetrics and Gynecology.

Subject and method: Based on literature analysis using database search engines PubMed, Google Scholar, Ovid in field of erythrocyte antibodies, laboratory diagnostics and clinical importance up-to-date knowledge.

Conclusion: Erythrocyte alloimunization anti-D antibodies decreases in connection with the introduction of immunoprofylaxis. Immunization of non RhD antibodies with impossibility using of immunoprofylaxis remains still clinical problem.

KEYWORDS alloimmunization – anti-D antibodies – prenatal diagnosis