Professor Marek Lubusky, MD, PhD, MHAProfessor Marek Lubusky, MD, PhD, MHA

Procházka M., Procházková J., Ľubušký M., Slavík L. Trombofilní stavy v porodnictví - I. část. Prakt. Gyn., 2004, 4, s. 12-17.


Thrombophilia is an inborn or accepted disorder of haemostatic mechanism, characterized as an increased tendency for blood coagulation and thrombotization. In gynaecology and especially in obstetrics they play an important role in ethiopathogenesis of many serious conditions and they are connected with higher risk of maternal and perinatal morbidity and mortality. At inborn forms it is especially the mutation of genes coding factor V-Leiden (Leiden mutation), prothrombin G20210A, further hyperhomocysteinaemia, autosomally inherited antithrombine deficit (AT) and C and S proteins. Among accepted forms there are malignity, nephrotic syndrome, protracted immobilisation, myeloprolipherative disease, postoperational conditions etc. Antiphospholipidic sydrome has a specific status.

Key words: thrombophilia – gravidity – coagulation

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Professor Marek Lubusky, MD, PhD, MHA

Department of Obstetrics and Gynecology
Palacky University Olomouc, Faculty of Medicine and Dentistry
University Hospital Olomouc
Zdravotníků 248/7, 779 00 Olomouc, Czech Republic
Tel: +420 585 852 785
Mobil: +420 606 220 644